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Milne Lecture: "From bits to bots: a mathematical perspective on generative AI"

By College of Science

Artificial intelligence is transforming the world—but how did we get here, and where are we going next?

Together, the College of Science Departments of Mathematics and Statistics, the College of Engineering Computer Science program and the Oregon State Center for Quantitative Life Sciences present the 2025 Milne Lecture.

Join us to hear Rachel Ward, an applied mathematician known for her work on machine learning, optimization and signal processing from the University of Texas at Austin and Microsoft Research, share a talk titled,

“From bits to bots: a mathematical perspective on generative AI.”

Data science and machine learning have undergone profound transformations in recent years, driven by the exponential growth of computational power and available data. In this talk, Ward will discuss the evolution from signal processing over half a century ago to the rise of machine learning and generative AI, highlighting mathematical foundations such as information theory, probability, linear algebra, and optimization. While modern AI research is becoming more empirical in recent years, we finish by highlighting open questions and directions where mathematicians and scientists are crucial for making foundational advancements.

When: Monday, June 2, 4–5 p.m. with a short reception beforehand

Where: OSU Corvallis, Cordley Hall, Room 1316

Whether you're studying STEM, already immersed in the field, curious about AI, or passionate about the future of technology, this lecture offers a compelling look at the science and mathematical principles behind the algorithms—and the opportunities ahead.

A man in a blue button shirt stands in front of nature.

Merging statistics and the environment: Science alumni gives back

By Hannah Ashton

In 1977, Steve Stehman (statistics, ‘82) was a junior at Penn State University studying biology. An independent study course had him knee deep in the streams of Centre County, Pennsylvania, collecting diatoms — tiny, unicellular photosynthesizing algae.

As he began to analyze his mountain of data, he quickly realized he was in over his head. This led him to enroll in a few statistics courses, where he discovered the powerful mutualistic relationship between biology and statistics.

Those tiny microscopic organisms changed the course of his life and put him on a path to the Department of Statistics at Oregon State, a place he believes stays one step ahead of the scientific trends and prepares students for every career outcome.

Today, as a Distinguished Teaching Professor at the State University of New York (SUNY) College of Environmental Science and Forestry, Stehman honors his roots by giving back to Oregon State. His contributions recognize the invaluable education he received and pay tribute to one very special faculty member.

OSU connections shaped a path to success

Oregon State was one of a few schools on a short list Stehman created for master’s degree options. Faculty at Penn State recommended OSU as a place where statistics and the environment were already coming together, something that wasn’t true at most universities.

“It has been a strength of the department for the last 50 or so years and I’m biased in my opinion, but I think they’re still one of the top places for combining the environment and statistics,” he said. “They have been very successful in being innovative and right at the front of changes that have occurred over the last few decades.”

A scholarship offer that covered his first year of tuition sealed the deal and he packed his bags to move across the country.

Once he arrived at Oregon State, he quickly found a sense of community, thanks to W. Scott Overton, a faculty member with a joint appointment with the forestry college. Overton’s academic career spanned a range of topics including wildlife, forestry, statistics, ecology, conservation and environmental issues. He was a pioneer in the application of hierarchy theory to ecosystem theory and modeling. His statistical specialty was sampling theory and design, with applications to environmental issues and monitoring programs.

Overton served as Stehman’s master’s advisor and along with his wife Joanne, he helped numerous graduate students feel at home.

“They had students out to their house for dinners and long discussions about statistics or life,” Stehman said. “That family relationship they invited people into, for me, was very helpful.”

When Stehman left Corvallis in 1983 to pursue a Ph.D. in Biometry at Cornell University, Overton still played a role in his education, receiving special permission to serve as his dissertation advisor.

“I get to learn about research and work with people who are addressing what I think are important problems.”

At the time, Overton was working closely with the Environmental Protection Agency, making major contributions to several aspects of the EPA’s National Surface Water Surveys conducted during the 1980’s and to the EPA’s Environmental Monitoring and Assessment Program (EMAP). Stehman worked with Overton on some of his research questions that had a direct environmental impact.

“I have always liked that I can ask researchers a lot of questions and learn about all these different things in the environment that otherwise I wouldn’t know about. You’re talking directly to an expert about their work, and they allow dumb questions because they recognize I don’t understand what they are doing,” Stehman said. “I get to learn about research and work with people who are addressing what I think are important problems.”

In 1989 he accepted a teaching position at SUNY in the Department of Sustainable Resource Management. Teaching wasn’t on his radar until his time at Oregon State. One of his degree responsibilities was spending one quarter as a teaching assistant.

“I put that off until my very last quarter because I wasn’t planning on being a teacher, but I had such a good experience that it was the spark for me to change directions and I decided it was something I was really interested in,” he said.

Stehman teaches sampling techniques, map accuracy assessment and experiment design and analysis of variance. These classes align with his passion for analyzing land cover mapping with satellite data. Although this type of work requires a narrow area of statistics, Stehman likes how it addresses problems with huge impact such as deforestation or changes in surface water availability.

“I’ve had a very narrow career specialized in that area, but these were the problems I wanted to work on. It’s been a lucky but perfect match of my interests and the work people are doing,” he said.

Once again, he owes it all to Overton. In 1989, before he left to teach back east, Stehman took a consulting job that Overton was offered but didn’t have time for. He spent the first three weeks of January in Fairbanks, Alaska, working with the U.S. Fish and Wildlife Service to assess the accuracy of vegetation maps derived from satellite imagery.

“To validate maps you select a small set of areas as a sample and then do very intensive work to try and see what exactly is there as close to the truth and then compare it to the map. There has been a lot of work over the years to try and do it more efficiently and accurately,” Stehman said.

In 2016, Stehman was named the SUNY College of Environmental Science and Forestry exemplary researcher for his outstanding research career and unsurpassed knowledge in his field of study.

Attending Oregon State helped Stehman narrow his field of study and develop a love of teaching, two things that would later define his entire career.

“It really did change things for me and put me on a career path I don’t think I ever would have started,” he said.

Two lemurs sit closely together on a tree branch, surveying their environment

Science Faculty Secures $18.5M in FY 2024, extending the reach and impact of science

By Hannah Ashton

The Everson lab studies Madagascan lemurs to explore how hybridization shapes genomes, species limits and the evolutionary trajectory of radiations (rapid increases in diversity).

The College of Science has a diverse portfolio of signature research, scholarship and innovation activities that enable our College to make fundamental and applied discoveries. To support society’s scientific challenges, we are invested in discovery-driven science and applied and transdisciplinary research. Our research intersects with all four research areas of priority outlined in OSU’s strategic plan, Prosperity Widely Shared.

Over the 2024 fiscal year (FY24: July 1, 2023 - June 30, 2024), the College of Science researchers received $18.5 million in research grants to support groundbreaking science. Most of that funding came from federal agencies and foundations in recognition of proposals with broad societal impacts, like increased human health, sustainable and clean energy and climate change mitigation. Our faculty pursue foundational and basic research projects and science education projects. Data science and Artificial Intelligence (AI) tools are increasingly becoming part of the fabric of much of our research. College of Science research expenditures in FY24 totaled $20.7 million.

The figure below illustrates the breakdown of funding sources for the College, with the National Science Foundation (NSF) and National Institutes of Health (NIH) each awarding about $5.1M.

Pie chart showing Science Research Funding, with details in the following caption

Research funding in 2023-24 ($18.5M total) comprised investments mostly from federal and state agencies, including the National Science Foundation (25.7%–$5.1M), National Institutes of Health (27.7%–$5.1M), Department of Energy and National Labs (9.3%–$1.5M), and others (8.8%—$1.6M). Additional funds were provided by other universities (9.5%—$1.7M), foundations (11.4%–$2.1M), foreign governments (0.2%–$40K) and industry (5.6%–$1M).

Research funding propels Team Science forward

Oregon State University is focused on big discoveries that drive big solutions. Many science faculty received grants last year in support of discovery-driven science, applied and transdisciplinary research science education and innovation in OSU’s priority research areas of integrated health and biotechnology, climate science and solutions, robotics, data science and AI, and clean energy and solutions. Below are some of the highlights—not including multi-year projects started before 2023.

Faculty honors

Astrophysicist Jeff Hazboun received a $73K Faculty Early Career Development award from the National Science Foundation. This prestigious NSF early career award is highly coveted by faculty! Hazboun’s project includes curriculum development and the implementation of a summer workshop in astrophysics-themed data analysis designed to foster inspired teaching, stimulate excitement in pulsar timing array research, facilitate the learning goals of undergraduate and graduate students, and support the community college students’ transition into four-year schools.

Mathematician Christine Escher received a $50,397 award from the NSF to host the Pacific Northwest Geometry Seminar series over three years at various Pacific Northwest universities. Escher is the principal organizer of the conference. This award supports meetings of the Pacific Northwest Geometry Seminar (PNGS), a regional meeting for researchers and educators of geometry, to be held at the University of British Columbia (2025), Seattle University (2026) and Lewis & Clark College (2027).

Integrated health & biotechnology

Materials scientist Kyriakos Stylianou, along with members of the College of Pharmacy and the College of Agricultural Science, received $2 million from the U.S. Department of Agriculture to develop improved ways of preventing stored potatoes from sprouting, particularly in the organic sector. Stylianou’s team studied nearly 200 different plant essential oils for their anti-sprouting effects. Oregon, Washington and Idaho produce more than 60% of the potatoes grown in the United States, and Pacific Northwest potato cultivation is a $2.2 billion industry.

Microbiologist Maude David is part of a multi-institution research team to receive a $4.3 million grant from the U.S. Department of Agriculture to study European foulbrood disease (EFD) in honey bees. The group is investigating the factors contributing to the high incidence of infection, and will then share their findings with local beekeepers and growers to improve mitigation efforts. Beekeepers in Oregon typically pollinate about five different crops annually. If the colonies are weakened by EFD, this results in less pollination, which is a concern for blueberry and almond growers.

A scientist in a beekeeping outfit stands next to a honeycomb

Carolyn Breece from the OSU Honey Bee Lab shows Maude David a bee colony during a field trip.

Evolutionary biologist Michael Blouin was awarded $1.86M over five years ($371K per year) from the National Institutes of Health for his project entitled, “Genetic mechanisms of snail/schistosome compatibility.” Schistosomes are water-borne blood-flukes transmitted by snails, which infect over 250 million people in more than 70 countries and cause severe and chronic disability. A debilitating helminth parasitic disease of humans, vaccines are available for schistosomiasis. This project will identify new genes that make some snails naturally resistant to infection by schistosomes, revealing potential new ways to reduce parasite transmission at the snail stage.

Statistician Robert Trangucci received $164K from the University of Michigan for his project entitled, “Data driven transmission models to optimize influenza vaccination and pandemic mitigation strategies.” Selection bias is common in infectious disease datasets due to complex observational and biological processes, and bias can arise from covariate data which is missing due to analytical limitations. The research team is addressing the concern by extending existing models to accommodate risk and data gaps over time for application in vaccination and other novel datasets.

Chemist Dipankar Koley received $542K from the National Institutes of Health for his project entitled, “Microenvironmental characterization and manipulation to prevent secondary caries.” A common reason for dental replacement is a recurrence of caries around existing restorations caused by microbial activity. The project seeks development of new and innovative materials to bias this microbial environment toward improved dental health, and the researchers are investigating the use of cations of magnesium and zinc applied with specialized release platforms.

Collaborative research at the interface of robotics, computer vision and AI

Statistician Yanming Di received $249K from the U.S. Department of Agriculture for a project entitled, “DeepSeed: A computer-vision network for onsite, real-time seed analysis.” The Willamette Valley is considered the “grass seed capital of the world.” Seed testing, used for determining seed lot quality and establishing seed value, is a fundamental phase of the agricultural marketing system. With recent advances in robotics, computer vision, and AI, an opportunity presents itself for a new wave of innovations. This project utilizes AI and robotics to innovate devices and protocols for sampling grass seeds and a computer vision system for automated seed analysis. The investigators consist of experts in seed services, computer vision, statistics, and mechanical engineering.

California mussels at low tide, covered in barnacles

Mytilus californianus (the California mussel) is prey for many predator species, serves as a filter for ocean particulate, and harbors hundreds of other species. Threats to this normally resilient foundation species represent risks to the entire local marine ecology.

Climate science and related solutions

Materials scientist Kyriakos Stylianou received $689K from Saudi Aramco for a project entitled “New Generation of CO2 Capture Adsorbents: Synthesis, Performance under Humid Conditions, and Scaleup.” In this project, the Stylianou group aims to discover novel adsorbents for the selective capture of CO2 from diluted sources. Successful materials will undergo scaling up and evaluation for their efficacy in removing CO2 from air.

Marine ecologist Bruce Menge received $200K from the National Science Foundation for his project entitled, “RAPID: A subtle epidemic: unique mortality of Mytilus californianus on the Oregon coast.”

The research team is investigating the major changes occurring in the Pacific Northwest marine ecosystems, with evidence these communities exhibit low resilience to climate change. For example, sessile invertebrates (mussels, barnacles, etc) become more abundant while seaweed species (kelp, etc) decline.

Evolutionary biologist Kathryn Everson received two awards for $276K from the University of Kentucky Research Foundation for a project entitled, “The role of hybridization in generating biodiversity: Insights from genomics of Madagascar’s true lemurs (Eulemur).” This project is funded by the NSF to understand how new species form in the context of complex gene flow and to expose the genomic signatures of evolutionary processes. The researchers will characterize patterns of gene flow, selection, and genome architecture for a species of lemur to gain a genomic perspective on the evolution of species boundaries. In addition, the team will construct a hybridization model using data on geographic range, diet, and social behavior for this lemur.

Clean energy and related solutions

Aerosol chemist Alison Bain received $284K from McGill University for her project entitled, “Single particle measurements.” This research aims to understand the optical properties of stratospheric aerosols. Using single particle experiments under environmentally relevant temperatures and humidities, the team will extend a wavelength-dependent refractive index model to include these conditions. They are also looking at how atmospheric aging impacts the optical properties of these materials.

Chemist Wei Kong received $110K from the American Chemical Society for her project entitled, “Superfluid helium droplets as microreactors for studies of photochemistry of fossil fuel hydrocarbons: polycyclic aromatic hydrocarbons and the corresponding endoperoxides.” The project will use superfluid helium droplets as microreactors to investigate the kinetics of the photooxidation process of a major component of petroleum (polycyclic aromatic hydrocarbons, PAH). Using several analytical techniques, the team will test the hypothesis that supercooling the helium droplets will stabilize an excited state of the oxygen molecule and prevent further reactions.

Collaborative partnerships to fuel a thriving world

Biochemist Ryan Mehl received $234K from the NobleReach Foundation in partnership with the National Science Foundation. The project “Ideal eukaryotic tetrazine ligations for imaging protein dynamics in live cells” was selected as one of the first set of 11 national pilot projects to receive $234K from the NobleReach Foundation.The partnership seeks to identify and accelerate the translation of NSF-funded research into biotechnologies and bio-inspired designs with commercial and societal impacts. This pilot will help inform future translational funding opportunities along with enabling Professor Mehl and the other selected principal investigators to accelerate bringing their research to the market and society.

Biochemist Patrick Reardon received $500K from the National Science Foundation (NSF) Research Instrumentation Program for his project entitled, “MRI: Acquisition of Helium Recovery Equipment: An integrated system for helium capture and recovery for the OSU NMR facility.” This award supports the acquisition and installation of an integrated system for helium capture and recovery for the nuclear magnetic resonance (NMR) facility. Helium is in high demand and is used for a wide variety of industrial and research applications, and it is a non-renewable resource which highlights the need for laboratories to capture and recycle this important gas. The NMR lab is supported by funding from the National Institutes of Health, NSF, M.J. Murdock Charitable Trust, and OSU, and it is a core facility and cornerstone for groundbreaking research in interdisciplinary science and engineering, chemistry, biochemistry, and biophysics at OSU, throughout the Pacific Northwest, and beyond. The facility continually strives to enhance its state-of-the-art instrumentation for the highest levels of analytical performance.

Mary Tunstall smiling for a photo under the sun in front of green leafy trees and bushes.

How this data analytics grad excels in everything remote

By Kaitlyn Hornbuckle

In West Virginia, Mary Tunstall once avoided the New River’s dangerous rapids at all costs. After all, if the raft flipped, she’d be responsible. But being a whitewater raft guide right out of high school taught her something more important: how to say, “I can do this” to overcome obstacles.

Like the river, Tunstall’s career journey roared with twists and turns. After graduating from the University of Virginia in 2009 with her bachelor’s in environmental science, she landed an internship with the U.S. Forest Service right outside of Vail, Colorado.

The draw of snowboarding in the cold and crisp Rocky Mountain snow kept her and her husband sticking around. Her journey snowballed when she found herself working the front desk at Manor Vail Lodge, a popular resort hotel with its own restaurant, outdoor pool, garden and luxury bar. Little did she know she would climb the ladder nine years later.

In 2018, Tunstall and her husband made the move to Toledo, Oregon to be closer to family. By working remotely for the same hotel as director of revenue and reservations, she had the flexibility to focus on her education.

When she discovered that Oregon State University offered a fully online master’s program in data analytics that could help her make a bigger impact in her career, she decided to take the plunge.

Mary Tunstall smiles with her rafting team. She sits in the middle wearing a blue jacket and hugging a friend.

Mary Tunstall sits in the middle (with the blue jacket) with her rafting team in West Virginia.

Tunstall is a data analytics student set to graduate with her master’s degree. On the way, she discovered that remote learning never kept her from success. In a way, it brought her closer.

“It's super important to be able to understand and draw conclusions from data. Having the ability to take that data, make meaningful conclusions from it and then be able to communicate it to others well is why data analytics is so important,” she said.

Floating through rough rapids

Completing an online master’s degree while working remotely full-time was no easy feat. Courses ranged from statistics to learning the R computer programming language and advanced mathematics skills. “I hadn’t taken calculus in 15 years, so I really struggled with the probability distributions and hazard functions,” she said.

After getting the lowest score she had ever earned on a quiz, she remembered what she told herself back in the day as a raft guide: “I can do this.” She pushed forward, and her professor’s support turned her struggle into a milestone.

“I never thought it would be possible to work with data like this — it’s a game changer.”

When she felt blocked by the low quiz score in the applied survival analysis course, Associate Professor Yanming Di steered her in a direction that mattered more.

“Once I got over the grade I got on this quiz, I was able to take what I learned from him from those biweekly office hours discussions, assemble everything I learned, post it to the class discussion board and ask for clarification,” she said.

Discussion boards are a great way for both students and professors to post online messages that everyone in the course can read. Taking advantage of this format, Tunstall assembled all the different mathematical functions, explained what they did and posted them to the discussion board. If her work was a little bit off, she saw feedback from her professor fast.

Tunstall holds a cute little white dog with her family in their backyard, smiling for a photo.

One of the perks of being an Ecampus student is being able to spend time with family. From left to right is Mary Tunstall's mother, father, and her husband, Paul.

As she tackled each concept, Tunstall’s passion for data analytics blossomed in the applied survival analysis course. Analyzing the effects of a treatment on patients with a liver disease called primary biliary cholangitis was her favorite project.

“For my project, I wanted to explore the effects of the treatment on each morphological stage of the disease. I wanted to see if there was an actual correlation between the timing of the treatment and the survival rate for each of the four stages,” she said.

Utilizing data sets in this way can reveal whether it’s beneficial to take the treatment for a disease in stage one versus stage three. The effects of treatment may vary depending on the stage, but the only way to see this is to look at the data.

“I never thought it would be possible to work with data like this — it’s a game changer,” Tunstall said. “I thought you had to have a medical degree to even touch data like that. But you don’t. So it’s been a really eye-opening experience — I don't know a lot about the disease and what causes it, but I can look at this data set and make recommendations that might be better for patients.”

Embarking on her next adventure

This summer, Tunstall is attending the in-person graduation ceremony in Corvallis. After that, she’s leaving some doors open.

“Ultimately what I’d like to do is land a career that’s more impactful. I would love to work for the federal government in some sort of capacity, especially in environmental sciences,” she said. “If it exists, being the director of data analysis with an organization like the Environmental Protection Agency would be a dream.”

She also credits her partner for standing by her side and making earning her master’s degree less stressful. “My husband, Paul, has been the one that’s been supporting me and cooking dinner when I’m busy working on my classes,” she said.

After celebrating this milestone with her family, she plans to leverage the skills she learned to improve her current role at the hotel. This includes automating some of the manual tasks she currently handles, allowing her to focus more on strategy and less time on tactics.

“I do revenue management as part of my job, which involves monthly forecasts for room revenue and analyzing data to make decisions. A lot of what I do right now is manual, so I’m really interested in implementing an exponential smoothing process,” she said. After she gets permission from IT to do so, she would automate the process it takes to predict the future using past data sets.

Being able to make these predictions can help the hotel make better financial decisions so that people can still enjoy the Rocky Mountains in luxury for years to come.

Her journey from rafting to survival analysis revealed endless possibilities, and Tunstall is along for the ride. To make a difference in the world, sometimes all it takes is saying, “I can do this.”

Mary Tunstall gives a peace sign while smiling with a group of friends on a raft in a river.

Mary Tunstall poses on a raft (on the left giving a peace sign) after going on a river trip with her team.

Two people stand in front of buildings.

Immune systems for cities: Lessons from the COVID-19 pandemic

By Hannah Ashton

Photo by Karl Maasdam

College of Science faculty and PIPP project leaders Katherine McLaughlin and Benjamin Dalziel pose for a picture.

This article originally appeared in the Oregon State University Stater Spring 2024 magazine. Read the full spread highlighting lessons from the pandemic across Oregon State, starting on page 42.

Cities are like organisms — they need immune systems.

Viruses can reproduce rapidly, taking over cells and turning them into viral factories within hours. Individuals' immune systems need to rise to the challenge, but what happens when they can't, and a whole population gets sick?

As the early days of the pandemic demonstrated, cities can struggle to stop the momentum of a spreading disease. Armed with community input and lessons learned over the past four years, a multidisciplinary team of researchers at Oregon State University is designing city-scale feedback loops to act as a kind of immune system for a population as a whole.

"We believe future cities will give people access to real-time local data on infection risk," said ecologist Benjamin Dalziel, project leader. "You'll be able to use that information in your daily life, like how you use a weather report. The more people do that, the slower the spread will be."

The team is supported by $1 million from the National Science Foundation through its Predictive Intelligence for Pandemic Prevention Program (PIPP).

The project began in 2022 with a series of workshops in cities across Oregon. "One key that communities stressed was the importance of sharing timely data between different groups and organizations — much like how different systems in the body communicate to mount an immune response," said team member Katherine McLaughlin, an applied statistician.

The researchers aim to establish a center at OSU that combines mathematical and computational modeling with engineering, public health and public engagement. The Center for Pandemic-Resilient Cities (CPARC; pronounced like "spark") will prototype city-scale feedback loops that link environmental monitoring with epidemic forecasting and communication, so responders won't have to play catchup after an outbreak begins.

Led by the College of Science, the effort capitalizes on OSU's strong tradition of multidisciplinary work and includes six university colleges. In the College of Engineering, Tyler Radniecki and Christine Kelly are developing innovations in wastewater sensing, a low-cost method of monitoring that involves testing sewage samples for disease.

Teams from the College of Health and OSU Extension and Engagement are working to ensure that the science incorporates the characteristics of different communities. For example, responders in cities with a lot of tourism need to know whether infection is spreading locally, such as within schools, or is arriving from other cities, as responses will be different in each case.

Faculty from the College of Liberal Arts (Daniel Faltesek) are researching how to use interactive media to communicate infectious disease forecasts to people in the city, to close the loop between prediction and prevention.

"Human systems, like cities, can be very good at making things 'go viral,'" said project leader Dalziel. "Using mathematics, engineering and community engagement, we can develop systems that make helpful responses go viral, too."

Sharmodeep Bhattacharyya stands in front of water in the background.

The backbone of science: OSU researcher champions the value of statistics

By Luke Nearhood

Statistics often operates behind the scenes. It’s a field whose results are used in the analyses of papers from physics to psychology, yet its power is not widely understood.

Associate Professor Sharmodeep Bhattacharyya wants to change that. He straddles the world of highly theoretical statistics—the foundational mathematics of statistics—and the application of statistics to other areas of science.

"Scientists in different fields should be more mindful of the statistics that they are trying to use because statistics are misrepresented and misused alarmingly often," Bhattacharyya said.

Understanding the brain

With collaborator Kristofer Bouchard, a scientist at Lawrence Berkeley National Laboratory, Bhattacharyya is currently examining the statistics of brain data measured using electrodes. The pair looked at data collected from placing electrodes on the exposed brains of lab rats, a process known as electrocorticography.

The data generated from those experiments is very high-dimensional, which in the context of math formalizes the concept of degree of freedom, something that can take on a value. In our everyday experience, we're used to thinking of ourselves as existing in three-dimensional space, where the coordinates–often called x, y and z–are our degrees of freedom. If you were unable to move freely in all three spatial directions and were instead constrained to walking along a rope, you would only have one degree of freedom and move only in one dimension.

In the brain data that Bhattacharyya and his collaborators examine, each dimension corresponds to the state of a specific neuron. Thinking of a neuron like a switch, a state would be whether or not it's on or off. But when a large portion of brain has to be studied the number of neurons present is multiplied, leading to a high-dimensional situation.

Given how many neurons there are in a small piece of rat brain, the experiments Bhattacharyya has looked at have thousands of dimensions.

Additionally, neurons "talk" to each other, forming a network. The activation of neurons also comes in waves and pulses, making the data sparse. These qualities make brain electrode data prime for the application of statistical techniques to find meaningful patterns.

Bhattacharyya's work on this project, and in general, is focused on the building of frameworks and understanding of methods. In the realm of theory, it can be a challenge to prove why a result that appears simple on the surface is true, or why a seemingly simple method works. Theoretical rigor makes a method reliable and allows practitioners from different domains to adapt the method smoothly. It also widens the scope of the method within the Statistics community itself.

When analyzing networks, community detection is important. A community is just what it sounds like; a group of interconnected people. For neurons, communities would be regions of the brain where neurons are tightly connected.

In the world of networks, neurons could be represented by what are known as ‘nodes’, while the connections between nodes are ‘edges’. For example, imagine a street grid, the intersections would be nodes, and the streets between them edges. The concept of communities is then generalized to include any group of nodes that are highly interconnected.

Detecting communities in networks isn't always obvious, especially for sparse networks. However, Bhattacharyya found a surprisingly straightforward method of community detection that works wonders at just this.

"It's a very simple method, but proving that this method works was not easy, so that took me quite a bit of time," he said.

Bhattacharyya has also worked with collaborators on public health policies, social networks and gene regulatory networks. These collaborations have offered him the opportunity to introduce fellow scientists to statistical methods, demystifying the perception of statistics as a black box.

"I'm very much interested in interdisciplinary work, specifically because I get to learn about a new field, as well as try to see how I can contribute to that field."

Every dataset is full of surprises, and that is one of the great wonders of statistics. It is also why all scientists need to understand statistics so they can apply the appropriate methods for their data, or find someone who can.

Guided by the data

Bhattacharyya grew up in the city of Kolkata, India. There, he completed his bachelor's and master's degrees at the Indian Statistical Institute (ISI) in 2006 and 2008 respectively. The ISI was founded in 1931 by statistician Prasanta Chandra Mahalanobis and is India's premier institute of higher education when it comes to the training of statisticians.

He completed his Ph.D. and postdoctoral program at UC Berkeley with statistics professor Peter Bickel. A pioneer of statistical methods, particularly in what are known as semiparametric models, Bickel is still publishing papers despite being semi-retired.

"Last year, we had his 80th birthday celebration conference at Berkeley, and several of his Ph.D. students who are now big shots in statistics attended. It was a very nice conference," Bhattacharyya said.

By the time Bhattacharyya completed his Ph.D. in 2013, Bickel had been in the field for 50 years. Bhattacharyya credits his current success to the wisdom, knowledge and experience his mentor shared with him. Bickel emphasized the importance of statistics always being guided by the data, with research questions informed by what the data says and what would benefit the broader statistics community.

Bhattacharyya’s transition to the Department of Statistics was a welcomed one. Although he grew up in a sprawling metropolis of 14 million people and completed his Ph.D. and postdoc in a city of four million, he always preferred the quiet life of the country and small cities. In part, it was a desire to get away from the hustle and bustle that brought Bhattacharyya to Corvallis.

The Department of Statistics encourages interdisciplinary research alongside more theoretical research, something Bhattacharyya holds in high regard. He also appreciated the incredibly welcoming department culture.

"I'm very much interested in interdisciplinary work, specifically because I get to learn about a new field, as well as try to see how I can contribute to that field," he said.

Outside of academics, Bhattacharyya enjoys listening to classical Indian music, reading fiction and non-fiction, and of course spending time with his wife. She is also a statistician who completed her Ph.D. at Oregon State.

A hand with pink painted thumbnail uses a phone with an orange survey on the screen.

Oregon by the Numbers: Survey Research Center helps clients master the art of surveys

By Luke Nearhood

Imagine working for the Department of Motor Vehicles, not as a desk clerk or driving test administrator, but at the central office in Salem. Imagine that you were tasked with ascertaining how best to allocate fuel tax revenue. This revenue comes from the tax on fuel purchased for cars and trucks, marine boats, off-highway vehicles and other motorized vehicles. How would you go about distributing the revenue to the agencies responsible for these vehicles?

A survey to determine the fuel used in each category might be a good option, but where to begin? The Oregon State University Survey Research Center is ready to help. Since 1973 the Survey Research Center (SRC) has been working with Oregon State faculty and state government agencies to help them conduct and analyze surveys.

In addition to working with more than 15 different agencies in Salem including the Oregon Department of Transportation, Oregon State Marine Board and Oregon Department of Fish and Wildlife, the SRC has worked with Oregon State University faculty and staff on a variety of projects. Examples range from investigations in applied economics to surveys of students graduating from the College of Science.

"It's fascinating because I learned so much about the state for each survey we work with," said Virginia Lesser, head of the Survey Research Center.

The art of survey design

The process of survey design involves first working with the client to determine the budget and the population to be surveyed. Throughout the entire process there is constant back and forth with the client to figure out exactly what they want and what is possible.

Sometimes clients come in looking to survey a specific segment of the population, such as people who use their service. However, there is often no way of knowing exactly who comprises that population. An important component in designing surveys is to determine and accurately define the population from which the results are gathered. In order to obtain measures of confidence around any estimates, probability sampling must be used.

With probability sampling, every member of the population has an equal chance of being surveyed because they are drawn from a random distribution.

In contrast, non-probability sampling involves selecting from a non-random distribution, such as those who seek out a survey to participate in. Due to the lack of a random selection of individuals, it's impossible to identify biases or compute other measurements. Therefore, data collected using non-probability sampling should be interpreted with caution due to the impact of selection bias.

"So the challenge I have is working with a client to figure out how to get the opinions they need when they don't know who the people are that use their service," Lesser said.

Once the population has been selected, there are three primary components to designing a survey: writing the questions, selecting the probability samples and correctly analyzing the survey data. Writing questions is a bit of an art. Good survey questions should be both unbiased and flow well within a questionnaire. The sample selection depends on the population one is looking to reach and the sampling design. The statistical analysis methods must account for the sampling design and any survey errors, such as nonresponse.

The future of survey distribution

Survey administration methods have evolved significantly over the last several years. Phone-based surveys are not used as much as they were 20 years ago due to the low response rates. Web surveys have become more prominent.

Today the Survey Research Center conducts most of its probability-based surveys using a hybrid web and mail approach, combining the usability of the internet with the higher quality and response rates of mail. This ensures reaching a wider array of demographics than either form would alone.

A key advantage of mail-based surveys is that one can easily mail out surveys to every address or a random sample of addresses in an area. The list of addresses used to select the probability samples for SRC surveys covers nearly 100% of all households in the US. The hybrid web and mail approach provides the opportunity for all selected households to respond either by mail or by web. Thus not all households need to have internet access.

Another method to contact survey participants uses email addresses. Email-based surveys may also be used in cases where the SRC or the client knows the email addresses for the population and know that all potential participants have access to email, for example surveys of Oregon State faculty and students.

Increasingly, more surveys are being conducted using non-probability online panels. These panels are composed of people volunteering to complete surveys in exchange for remuneration or other benefits. They have become popular in recent years due to how cheaply and easily they can be used to get relatively large samples. However, the individuals from an online panel who complete a survey are not a random sample of the population. These respondents choose to actively participate because of personal interest, or because of some sort of incentive, such as a gift card.

Due to their self-selecting nature, estimates from non-probability panel surveys tend to be biased as compared to results from probability sampling methods. Relying on non-probability panels for unbiased information would be like relying on a jury entirely made up of people who really want to be on it.

In addition to its work helping others conduct surveys, the Survey Research Center staff also conduct original research. The main focus of their research is on comparing the effectiveness of different survey techniques, studying how even minute details such as envelope color and size, incentives and content of cover letters impact response rates.

Survey response rates continue to decrease and the research conducted by the SRC examines methods to improve response rates in their surveys. Recently, one of Lesser’s graduate students has been working on how to combine probability and non-probability samples, and thus how to integrate the two approaches.

In our ever-changing social and technological landscape, keeping a finger on the pulse of public opinion is vital. The behind-the-scenes work of designing survey questions and researching survey methods is just as vital. For the past 50 years, the Survey Research Center has done both, through their original research and the services they provided to their clients within and without Oregon State University.

A physicist works to zoom in on a microscope

New grants to support breakthrough discoveries

By Hannah Ashton

Four-dimensional tissue self-assembly, integrated river health and ultra-tiny spectrometers: The 2022 College of Science Research and Innovation Seed (SciRIS) award recipients will use collaboration to fill critical knowledge gaps across numerous scientific disciplines to drive real-world impact.

The SciRIS program funds projects based on collaborative research within the College of Science community and beyond. There are two tracks through the program: SciRIS (Stages 1-3) and the SciRIS individual investigator award (SciRIS-ii).

SciRIS Stages 1-3 funds teams in three stages of increasing funding to support training, research and capacity-building, accelerating work toward external funding opportunities. SciRIS-ii funds individual faculty to establish research relationships with external partners, enabling them to demonstrate the feasibility of their ideas and quickening the pace of scientific discovery.

SciRIS-ii Awardees

The following three scientists received SciRIS-ii awards: Bo Sun, Clayton Petsche and Ethan Minot.

Associate Professor of Physics Bo Sun’s research aims to lay the foundation for programmable four-dimensional tissue self-assembly. Current technologies have been unable to harness these naturally occurring processes to assemble dynamic tissue structures for biomedical and therapeutic applications. Four-dimensional tissue self-assembly is critical for many physiological processes including acute wound healing and in lethal tumor metastasis.

Sun and his collaborator, Yang Jiao from Arizona State University, will be building on eight years of collaborative research in the field of cell mechanics and cell migration that has resulted in eight publications.

Associate Professor of Mathematics Clayton Petsche will use his SciRIS grant to help three graduate students complete sub projects within the realm of arithmetic dynamical systems. The research will be entirely student-focused and will help establish their research credentials before entering the postdoctoral job market.

Professor of Physics Ethan Minot will use his award to bring ultra-miniaturized spectrometer technology to Oregon State and pursue follow-up opportunities.

In 2022, with co-authors from Finland, Minot was part of a study published in Science that resulted in a powerful, ultra-tiny spectrometer. Contributing to a field known as optical spectrometry, their discovery could improve everything from smartphone cameras to environmental monitoring.

Minot plans to bring the technology to Oregon to grow the new field of research.

SciRIS Stage 1 Awardees

Four groups of scientists received SciRIS Stage 1 awards up to $10K.

Associate Professor of Statistics Yuan Jiang, along with Anna Jolles, professor in the Department of Integrative Biology, received a SciRIS Stage 1 grant for a project which will help fill a knowledge gap and provide crucial tools to understand microbial community dynamics.

The team will develop a novel analytical pipeline that harnesses longitudinal microbiome data to define the ecological roles of host-associate microbes. Although the accumulation of microbial communities is essential to animal health, there are few statistical routes adequate for characterizing microbial community dynamics through time.

Integrative Biology Professor Anna Jolles and Carson College of Veterinary Medicine Professor Claudia Häse will use their SciRIS Stage 1 award to study eco-evolutionary host-bacterial-phage dynamics. Collaborating with a researcher from the University of Louisiana, the group will be using the Pacific oyster and shellfish pathogen Vibrio coralliilyticus as a model system.

In a project entitled “Bioinformatics for integrated river health,” Integrative Biology Professors David Lytle and Anna Jolles, along with Justin Sanders from the Carson College of Veterinary Medicine, will bring together expertise across disciplines to provide an integrated approach to understanding river health. The group will combine expertise in bioinformatic and genetic methods for characterizing aquatic invertebrate communities, aquatic parasite and pathogen communities, and fish microbiomes. Samples will come from the lower Colorado River, an ecologically and culturally significant ecosystem.

Biochemistry and Biophysics Associate Professors David Hendrix and Colin Johnson, along with Professor of Chemistry Claudia Maier and Patrick Reardon, director of the Nuclear Magnetic Resonance Facility at Oregon State, received a SciRIS Stage 1 award to create a pipeline of computational and experimental methods for the prediction, identification and functional characterization of microproteins. Previously dismissed due to their small size, microproteins are now thought to play significant physiological roles including pathological roles in cancer progression.

Disease Mechanism and Prevention Fund

Researching Parkinson’s disease, Associate Professor of Biochemistry and Biophysics Alysia Vrailas-Mortimer received a grant from the College of Science Disease Mechanism and Prevention Fund for a project entitled “Why is a fly a good model to study my grandmother’s tremors?”

Similar to the SciRIS-ii, the fund is focused on assisting individual faculty efforts to establish research relationships with external partners for projects specifically related to health science.

Using fruit flies, Vrailas-Mortimer’s goal is to determine how a stress response protein protects against Parkinson’s-associated iron-induced oxidative damage. Parkinson’s affects over one million people in the U.S. and her research could provide the basis for future therapeutic strategies.

Oregon waterfall cascading down a cliffside surrounded by lush green trees.

A sustainable future: Unravelling the data

By Mary Hare

With areas of distinction in marine science, materials science, data science, biomedical science – and other research areas, OSU faculty and students are fighting climate change and moving the world forward to a greener future – whether that is through harnessing new materials, interpreting complex data or reimagining how organisms can adapt to changes. We share just a few examples in this three-part series.

Oregon State University scientists are rapidly rising to the challenge of our changing climate, supported by hundreds of graduate and undergraduate researchers who are committed to leaving a better world than the one they inherited. In part three of this series, we examine some of the data-driven research that is helping usher in a new era of climate policy and action.

Mathematics and statistics are two of the quickest-growing fields in the country, and it's not hard to guess why. As technology advances, mathematical modeling or statistical analysis can provide a faster, more reliable way to examine lots of data. In practice, these skills can provide critical insight to collaborative projects or inform policymakers on the most environmentally sound decisions.

Wildlife behavior

Making green energy safer for wildlife

Professor of statistics Lisa Madsen and statisticians from the United States Geological Survey (USGS) have come together to develop methodology to estimate the total mortality of bats, birds and other small creatures on wind farms and solar facilities. The Endangered Species Act requires that wind farms pay particular attention to endangered or threatened species such as golden eagles, brown pelicans, whooping cranes, condors and Indiana bats, which are killed when they accidentally collide with turbine blades.

Madsen and her colleagues have developed complex statistical tools that estimate the actual number of carcasses when they are undetectable for any reason by taking into account a host of predictor variables such as searcher efficiency, variations in plot sizes and location of inaccessible areas.

The software package, created by the team, will be utilized by government agencies as well as Western EcoSystems Technology, Inc., which has already begun to implement the software to assist their clients. The project has also attracted attention from environmental and government agencies in Canada, South Africa, Portugal and Scotland among others. In addition, the USGS statisticians have conducted workshops demonstrating how to use the software to estimate animal mortality at wind and solar energy facilities.

Wildebeast heard crosses the Mara River in Kenya

A recent study shows that groups of organisms that act together, like this wildebeest herd crossing the Mara River in Kenya, have complex relationships with their ecosystems. Not only are these mass movements affected by the external forces of their environments – they also shape the processes around them. These relationships have a powerful role in the behavior of the group, as well as in the health of the ecosystem.

Collective movement to stabilize ecosystems

In addition to being visually stunning, schools of herring, herds of wildebeest and countless other groups of organisms that act in concert can help complex ecosystems maintain their diversity and stability. Published in Nature Ecology and Evolution, a study led by mathematical biologist Benjamin Dalziel demonstrates that when individuals band together to consume resources as a collective group, the surrounding ecosystem is prone to be more resilient and able to support a wider range of species.

Their findings could be an important step toward understanding how cooperation and biodiversity help living systems stay on an even keel. “We constructed simulations in such a way that we could turn collective behavior on and off without changing anything else in the system,” Dalziel said. “What we found was that adding collective behavior was a game changer in the simulations – it stabilized ecosystems.” Since collective behavior is ubiquitous across the planet, playing a prominent role in everything from bacterial biofilms to human cities, the study’s findings have wide significance.

Bromus tectorum (cheatgrass)

In the sagebrush steppe of the intermountain West, invasive species like cheatgrass (Bromus tectorum) change soil composition and increase fire intensity and frequency, effectively squeezing out integral vegetation like sagebrush. Post-fire seeding efforts give sagebrush a fighting chance to recover from the impact of this interloper.

Data-driven resource management

The need for native seeds

Climate change and irresponsible land use have resulted in the degradation of millions of acres of land around the country. These disturbances are detrimental to native plant health and often creates opportunities for invasive species to thrive.

Statistician Virginia Lesser served as a panel member for a committee to assess the Need for Native Seeds and the Capacity for Their Supply, sponsored by the National Academies of Sciences, Engineering and Medicine. Native seeds play an essential role in maintaining and restoring natural areas. The committee explored the complex systems of native seed production and use in the United States, and examined their viability for future projects. Their committee was formed in 2019 and developed an interim report in 2020, with a final report expected in 2022.

Smarter forestry practices for a drier climate

As the earth warms, scientists in the Pacific Northwest can be sure of two things: rising temperatures and drier summers. In a state that relies heavily on Douglas fir trees - as a habitat for wildlife as well as economically - understanding how changing temperatures affect forest growth patterns will be critical for forest management. In a collaboration with the College of Forestry, statistics professor Lisa Ganio published a study that found that minor differences in temperature, soil depth or moisture did not significantly influence tree growth patterns. However, growth patterns were significantly impacted by competition, with higher growth in less competitive areas. The results of this study suggest that foresters will be able to focus more attention on other areas, such as habitat preservation.

Changing flood regimes, new projections

The potential for changes in flood regimes due to climate change, in combination with the deep limitations of climate projections, necessitates rethinking how we make flood risk management decisions.

Statistics professor Alix Gitelman participated in a study to develop a new approach for dealing with hydrologic uncertainty and flood management. The developed bottom-up approach was applied to the American River, CA, USA flood management system by first identifying the sensitivity and vulnerability of the system to different climates. To do this, they developed a climate response surface by calculating and plotting Expected Annual Damages (EAD, $/year) under different flood regimes.

Siuslaw National Forest of Oregon

The time it takes a forest to recover after high-severity fires has important implications for how the landscape will respond in the future to changing fire regimes. A warming planet could delay forest recovery by either hindering tree seedling establishment and growth, or through the loss of seed sources if patches of high-severity fire become larger.

Bolstering fire resistance in a changing climate

As fires become more prevalent throughout the west, landscapes are altered in ways that may make them more or less resilient to fire in the future. Enrique Thomann, a mathematics professor, participated in a study published in the Journal of Ecology to examine how changing ecological composition impacts the landscape's ability to resist fire damage in the future - an area that continues to be under-researched.

As the climate warms, there is a growing concern that forest landscapes risk transformation to non- forest systems through alteration of their fire regimes. Fire modifies vegetation composition and structure, including effects on fuel amount and type, fuel connectivity, and canopy- mediated influences on microclimate and fuel moisture. These effects may then shape the spread and severity of subsequent fires.

The strength of fire–vegetation feedbacks (i.e., the degree to which fire- driven changes to vegetation, fuels and microclimate affect the spread and behavior of subsequent fires) is influenced by numerous global change pressures. Given the many interacting variables that influence how ecosystems respond to disturbance, models calibrated to a specific study area are highly valuable in evaluating how that ecosystem responds to alterations of its disturbance regime.

Helping mitigate energy disasters in the Arctic

With expertise that spans disciplines, mathematics professor Malgo Peszynska primarily works on problems related to energy engineering and climate change. Her modeling of transport includes porous media phenomena in aquifers, oil and gas reserves, carbon sequestration, solar cells and the effect of permafrost warming. Perhaps most notable is her use of computational mathematics to model methane hydrate transfer and evolution.

Methane hydrate is an “ice” found primarily in the Arctic permafrost as well as in sub-ocean sediments. Known as one of the largest potential sources of fossil fuel, it is also one of the most risky. Existing in a delicate pressure-temperature equilibrium, exposure to heat could lead to melting that could cause explosions, or the escape of huge quantities of methane gas into the atmosphere.

The specific conditions at which it exists have also meant that it has been exceedingly difficult to study using traditional research tools. This is where using mathematics can be so useful. “As an applied mathematician in this area, the objective is to provide reliable and accurate modeling tools for simulation of various scenarios to help mitigate and contain the possible disasters,” Peszynska said.

Leaving a better world

As one of only three Land-, Sea-, Space- and Sun-Grant institutions in the country, Oregon State University has a commitment of service that extends beyond our campus, state or country borders. Students not only have the opportunity to receive a world-class education, but the opportunity to perform high-level research with faculty who genuinely care about the future of the planet - whether they are biologists, physicists or statisticians.

DNA strands.

Research grants to seed the next great idea

By Grace Peterman

College seed funding supports diverse projects with the power to directly impact human quality of life.

Seed funding from the College of Science Research and Innovation Seed (SciRIS) program continues to bolster ambitious and expansive projects, empowering our scientists to delve into fundamental research discoveries and translate them into revolutionary applications. Founded in 2018, the SciRIS program provides funding for collaborative projects that pursue fundamental discoveries and create societal impact, accelerating the pace of research, discovery and innovation in the College of Science.

Between 2019 and 2021, the SciRIS program provided $763K in seed funding to scientists leading research projects in both basic and applied science and mathematics, with the potential to produce practical solutions for industry, people and the planet.

There are two pathways through this program, the SciRIS Stages 1-3 awards and the SciRIS individual investigator award (SciRIS-ii). The SciRIS Stages 1-3 program funds teams in three stages, ranging from $10K to $125K, to foster team development, build capacity and accelerate project development for procuring larger external grants, while the SciRIS-ii program provides funds ranging from $10K to $20K to individual investigators to establish partnerships, accelerate project development, generate data and manuscripts and foster proposal submissions.

The 2022 Science Research and Innovation Seed Individual Investigator awards (SciRIS-ii) are catalyzing initiatives that will open fresh pathways in science.

Supporting pure and applied mathematics, agriculture, gene therapy, molecular movie technology and quantum mechanics

Radu Dascaliuc, a man with glasses and a beard.

Radu Dascaliuc, associate professor of mathematics

Dascaliuc researches stochastic cascades and energy transfer in equations of fluid dynamics. The mathematics of fluid flows allow us to understand and predict the complexity of behaviors exhibited in fluids. Deeply rooted in questions of applied science and engineering, the proposed research is a part of a larger program aimed at exploring connections between the mathematics of equations of fluid motions and physics of fluids.

Part of the proposal is to organize a two-week summer collaborative research program for graduate and undergraduate students. This program will be devoted to attracting students from backgrounds traditionally underrepresented in STEM and especially in the field of fluid dynamics. The project will be structu­­red so that students without advanced knowledge in differential equations, mathematical analysis and probability can contribute and hopefully become interested and motivated to learn more about the mathematics involved. Funds for Dascaliuc’s SciRIS-ii project titled, “Stochastic Cascades and Energy Transfer in Equations of Fluid Dynamics” are provided by a generous gift made to the Robert W. Lundeen Science Faculty Development Award Fund.

Yanming Di, a man with glasses standing outside.

Yanming Di, associate professor of statistics

In partnership with the Oregon State Seed Lab, Yanming Di innovates seed sampling devices and protocols. Seeding testing — used for determining seed lot quality and establishing seed value — is a fundamental phase of the agricultural marketing system. Getting an accurate subsample of seed depends on the accuracy and precision of the device used.

Devices and protocols developed by the OSU Seed Lab and the USDA in the 1970s are still considered state of art today, leaving ample room for further improvements. With SciRIS funding, Di and collaborators aim to start a new wave of groundbreaking innovations by incorporating recent advances in robotics, computer vision, machine learning and stochastic modeling into seed testing. Funds for Di’s SciRIS-ii project entitled “Innovating Seed Sampling Devices and Protocols” come from the College of Science’s Education & General Funds.

Colin Johnson, a man with a red beard.

Colin Johnson, associate professor of biochemistry and biophysics

Colin Johnson’s research uncovers new connections between the ferlin family of genes and disease. Mutations in dysferlin are linked to muscular dystrophy, while mutations in otoferlin and myoferlin have been linked to deafness and breast cancer, respectively. Previous research led by Johnson uncovered key components of otoferlin gene therapy, moving one step closer to restoring hearing for the congenitally deaf.

In partnership with collaborators from the College of Engineering and College of Agricultural Sciences, Johnson’s new project will focus on ferlin gene Fer1L6, which has been linked to ovarian failure and neural tube development deficiencies. It will be the first study to unpack the effects of Fer1L6 on organismal development and neural tube defects. Funds for Johnson’s SciRIS-ii project, entitled “Establishing a Zebrafish model for the study of the Ferlin gene Fer1L6,” come from the College’s Education & General Funds.

Chong Fang, a man in glasses.

Chong Fang, associate professor of chemistry

SciRIS-ii funding will support a research collaboration between OSU and Stanford University led by Chong Fang. The project will implement state-of-the-art femtosecond laser spectroscopy at the Linus Pauling Science Center. By advancing the mechanistic knowledge and rational design of reversibly photoswitchable fluorescent proteins, this emergent tool for super-resolution microscopy and bioimaging will elevate both labs’ research to new heights while further enhancing the visibility and impact of “molecular movie” technology at OSU.

Funds for Fang’s SciRIS-ii project, entitled “Elucidating primary events of engineered photoswitchable fluorescent proteins with a powerful ultrafast spectroscopy toolset,” are provided by a generous gift made to the Ben and Elaine Whiteley Materials Research Fund.

Man smiling in front of a bush of flowering azaleas

Clay Petsche, associate professor of mathematics

Petsche is working with graduate students Chifan Leung, Chatchai Noytaptim and Peter Oberly to develop new ways to measure the arithmetic complexity of dynamical systems – a mathematical construction which takes input data and feeds it through a repetitive process – and to show that certain families of arithmetic dynamical systems can be divided into the simple and the complex. Using mathematical techniques including Galois theory, which is the study of symmetry in the solutions to polynomial equations; potential theory; and the analytic theory of Berkovich spaces, a fully modern construction that has recently given mathematicians the ability to apply classical analytic techniques toward modern number theory applications.

Funds for Petsche’s SciRIS-ii project, entitled “Exceptional maps in arithmetic dynamical systems,” are provided by a generous gift made to the Robert W. Lundeen Science Faculty Development Award Fund.

 Axel Saenz Rodriguez, a man with dark hair.

Axel Saenz Rodriguez, assistant professor of mathematics

According to quantum mechanics, we can only know the probability for the location of an electron at any given moment. Yet, if the electrons are confined to a one-dimensional space, the system exhibits certain symmetries that may allow one to obtain exact formulas for the statistics of the electrons. Axel Saenz Rodriguez aims to develop the mathematical theory to determine these statistics and to host a conference focused on this research topic. The two-day conference at OSU in Fall 2022 will build a regional network of collaborations; develop research projects suitable for grant proposals; and build research activity and a community on campus for graduate students and faculty. Funds for Saenz Rodriguez’s SciRIS-ii project, entitled “Probability law for 1D quantum electrons,” are provided by a generous gift made to the Robert W. Lundeen Science Faculty Development Award Fund.

Bolstering medicine through interdisciplinary research

As part of the SciRIS program, the College of Science offers other donor-funded awards to bolster research and innovation. The Disease Mechanism and Prevention Fund (DMPF) supports research into the mechanism, diagnosis, treatment and prevention of human disease by the College of Science faculty. These funds are provided by a generous gift from David and Donna Gould. The awardees are Swati Patel, assistant professor of mathematics and Adrian Gombart, professor of biochemistry and biophysics.

Swati Patel, a woman with dark hair.

Swati Patel, assistant professor of mathematics

Swati Patel’s DMPF proposal is titled “Mathematical modeling of Anthelmintic resistance in soil-transmitted Helminths.” Patel’s research addresses soil-transmitted helminths (STH), parasitic worms that infect an estimated 1.5 billion people worldwide, particularly in developing tropical countries that lack adequate sanitation systems. Periodic de-worming is necessary to treat and prevent infection, but STH are developing resistance against the drugs used. Patel develops projects to investigate the mechanisms that lead to resistance and strategies to prevent it through systematic mathematical modeling.

Adrian Gombart, professor of biochemistry and biophysics.

Adrian Gombart, professor of biochemistry and biophysics

Gombart’s DMPF project, “The role of the cathelicidin antimicrobial peptide in the development of Alzheimer’s disease,” continues work from a previous DMPF award, studying the potential use of an antimicrobial peptide called cathelicidin to curtail the development of Alzheimer’s. Vitamin D and other nutrients regulate expression of the peptide. Gombart’s project could lead to further development of effective preventative therapies or treatments of Alzheimer’s disease. Gombart is a principal investigator at the Linus Pauling Institute and is known for his extensive research on the uses and functions of vitamin D, including using it to combat infection via wound dressings and sutures.

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